Abstract
We report pilot studies to evaluate the susceptibility of common domestic livestock (cattle, sheep, goat, alpaca, rabbit, and horse) to intranasal infection with SARS-CoV-2. None of the infected animals shed infectious virus via nasal, oral, or faecal routes, although viral RNA was detected in several animals. Further, neutralizing antibody titres were low or non-existent one month following infection. These results suggest that domestic livestock are unlikely to contribute to SARS-CoV-2 epidemiology.
Keywords:
SARS-CoV-2; alpaca; cattle; goat; horse; livestock; rabbit; sheep.
MeSH terms
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Animals
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Antibodies, Neutralizing / blood
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Antibodies, Neutralizing / immunology
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Antibodies, Viral / blood
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Antibodies, Viral / immunology
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COVID-19 / immunology
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COVID-19 / veterinary*
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COVID-19 / virology
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Camelids, New World / virology
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Cattle / virology
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Chlorocebus aethiops
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Disease Reservoirs / virology
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Goats / virology
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Horses / virology
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Host Specificity* / immunology
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Humans
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Livestock / virology*
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Nasal Cavity / virology
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RNA, Viral / analysis
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Rabbits / virology
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Rectum / virology
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Respiratory System / virology
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SARS-CoV-2 / genetics
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SARS-CoV-2 / isolation & purification
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SARS-CoV-2 / pathogenicity*
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Sheep / virology
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Species Specificity
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Vero Cells
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Virus Shedding
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Viscera / virology
Substances
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Antibodies, Neutralizing
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Antibodies, Viral
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RNA, Viral