Survival With Surgery Is Superior to Survival Without Surgery in Breast Cancer Patients Aged 85 years or Older: A Retrospective Study

Am Surg. 2021 Nov;87(11):1746-1751. doi: 10.1177/00031348211054067. Epub 2021 Nov 6.

Abstract

Background: Surgical treatment of breast cancer patients aged 85 years or older is still controversial.

Methods: A series of surgically treated breast cancer patients aged 85 years or older was evaluated. The clinicopathological features and outcomes of these patients were compared with the features and outcomes of breast cancer patients in the same age group who were managed without surgery.

Results: A total of 45 patients (75%) received surgical treatment, and 15 patients (25%) were managed without surgery. Significantly more patients treated by surgery underwent systemic treatment than patients managed without surgery (P = .003). The 5-year disease-free survival rate of patients treated by surgery was 80.7% (95% confidence interval: 66.2-98.5%), which was significantly higher than that of the patients managed without surgery (P = .001).

Conclusions: The surgical treatment of breast cancer patients aged 85 years or older is warranted. This outcome was achieved with the use of hormonal therapy.

Keywords: breast neoplasms; geriatric surgery; non-surgical treatment; surgical treatment; survival outcome.

MeSH terms

  • Age Factors
  • Aged, 80 and over
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Breast Neoplasms / mortality
  • Breast Neoplasms / pathology
  • Breast Neoplasms / surgery*
  • Breast Neoplasms / therapy
  • Female
  • Humans
  • Mastectomy / methods
  • Mastectomy / mortality
  • Radiotherapy
  • Retrospective Studies
  • Survival Analysis

Substances

  • Antineoplastic Agents, Hormonal