Molecular Hydrogen: A Promising Adjunctive Strategy for the Treatment of the COVID-19

Yingning Li; Zhen Wang; Naqi Lian; Yuzun Wang; Weiqiang Zheng; Keliang Xie

doi:10.3389/fmed.2021.671215

Molecular Hydrogen: A Promising Adjunctive Strategy for the Treatment of the COVID-19

Front Med (Lausanne). 2021 Oct 22:8:671215. doi: 10.3389/fmed.2021.671215. eCollection 2021.

Authors

Yingning Li¹, Zhen Wang¹, Naqi Lian¹, Yuzun Wang¹, Weiqiang Zheng¹, Keliang Xie^{1

2

3}

Affiliations

¹ Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin Research Institute of Anesthesiology, Tianjin, China.
² Department of Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin, China.
³ College of Anesthesiology, Translational Research Institute of Intensive Care Medicine, College of Anesthesiology, Weifang Medical University, Weifang, China.

Abstract

Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has no specific and effective treatment. The pathophysiological process of the COVID-19 is an excessive inflammatory response after an organism infects with a virus. Inflammatory storms play an important role in the development of the COVID-19. A large number of studies have confirmed that hydrogen has a therapeutic effect on many diseases via inhibiting excessive inflammatory cells and factors. Recently, a study led by the Academician Zhong Nanshan in China on the treatment of the patients with the COVID-19 by inhalation of a mixed gas composed of hydrogen and oxygen has attracted widespread international attention and hydrogen therapy has also been included in a new treatment plan for the COVID-19 in China. This study mainly describes the mechanism of occurrence of the COVID-19, summarizes the therapeutic effects and underlying mechanisms of hydrogen on the critical disease, and analyzes the feasibility and potential therapeutic targets of hydrogen for the treatment of the COVID-19.

Keywords: COVID-19; cytokines; inflammation; molecular hydrogen; treatment.

Publication types

Review