Altered diversity and composition of gut microbiota in patients with allergic rhinitis

Mu-Shi Zhou; Bin Zhang; Zhao-Lin Gao; Ru-Ping Zheng; Dama Faniriantsoa Henrio Marcellin Marcellin; Adonira Saro; Jing Pan; Ling Chu; Tian-Sheng Wang; Ju-Fang Huang

doi:10.1016/j.micpath.2021.105272

Altered diversity and composition of gut microbiota in patients with allergic rhinitis

Microb Pathog. 2021 Dec;161(Pt A):105272. doi: 10.1016/j.micpath.2021.105272. Epub 2021 Nov 2.

Authors

Affiliations

¹ Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
² Shanghai Clinical Research Center, Shanghai, China.
³ Department of Pathology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁴ Department of Otolaryngology-Head and Neck, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: tianshengwang@csu.edu.cn.
⁵ Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hunan, China. Electronic address: huangjufang@csu.edu.cn.

PMID: 34740809
DOI: 10.1016/j.micpath.2021.105272

Abstract

Background: Recently, multiple studies have suggested an association between gut dysbiosis and allergic rhinitis (AR) development. However, the role of gut microbiota in AR development remains obscure.

Methods: The goal of this study was to compare the gut microbiota composition and short-chain fatty acid (SCFAs) differences associated with AR (N = 18) and HCs (healthy controls, N = 17). Gut microbiota 16SrRNA gene sequences were analyzed based on next-generation sequencing. SCFAs in stool samples were analyzed by gas chromatography-mass spectrometry (GC-MS).

Results: Compared with HCs, the gut microbiota composition of AR was significantly different in diversity and richness. At the phylum level, the abundance of Firmicutes in the AR group were significantly lower than those in the HCs group. At the genus level, the abundance of Blautia, Eubacterium_hallii_group, Romboutsia, Collinsella, Dorea, Subdoligranulum and Fusicatenibacter in the AR group were significantly lower than that in the HCs group. The concentrations of SCFAs were significantly lower in the AR group compared with the HCs group. Correlation analysis showed that the Eubacterium-hallii-group and Blautia correlated positively with SCFAs.

Conclusion: Our results demonstrate compositional and functional alterations of the gut microbiome in AR.

Keywords: Allergic rhinitis; Gut microbiota; SCFAS.

MeSH terms

Dysbiosis
Feces
Gastrointestinal Microbiome*
Humans
Rhinitis, Allergic*