Exciting new tools for studying TREM2 in dementia

Georgina E Menzies; Megan Torvell

doi:10.1016/j.str.2021.10.009

Exciting new tools for studying TREM2 in dementia

Structure. 2021 Nov 4;29(11):1215-1216. doi: 10.1016/j.str.2021.10.009.

Authors

Georgina E Menzies¹, Megan Torvell²

Affiliations

¹ Dementia Research Institute and School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff CF10 3AT, UK.
² Dementia Research Institute and Department of Immunology and Infection, School of Medicine, Cardiff University, CF24 4HQ, UK. Electronic address: menziesg@cardiff.ac.uk.

PMID: 34739822
DOI: 10.1016/j.str.2021.10.009

Abstract

TREM2 has long been implicated as an Alzheimer's disease (AD) risk gene. In this issue of Structure, Szykowska et al. (2021) generate antibody single-chain variable fragments (scFvs) to the immunoglobulin(Ig)-like domain of human TREM2. They present two co-crystalized structures and characterize the functional impact of these scFvs on TREM2.

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MeSH terms

Alzheimer Disease*
Humans
Membrane Glycoproteins
Receptors, Immunologic

Substances

Membrane Glycoproteins
Receptors, Immunologic
TREM2 protein, human