Intelligent Pore Switch of Hollow Mesoporous Organosilica Nanoparticles for High Contrast Magnetic Resonance Imaging and Tumor-Specific Chemotherapy

Lin Huang; Jie Feng; Wenpei Fan; Wei Tang; Xiaoxiang Rong; Wangjun Liao; Zhenni Wei; Yikai Xu; Aiguo Wu; Xiaoyuan Chen; Zheyu Shen

doi:10.1021/acs.nanolett.1c03130

Intelligent Pore Switch of Hollow Mesoporous Organosilica Nanoparticles for High Contrast Magnetic Resonance Imaging and Tumor-Specific Chemotherapy

Nano Lett. 2021 Nov 24;21(22):9551-9559. doi: 10.1021/acs.nanolett.1c03130. Epub 2021 Nov 5.

Authors

Lin Huang¹, Jie Feng¹, Wenpei Fan², Wei Tang³, Xiaoxiang Rong⁴, Wangjun Liao⁴, Zhenni Wei⁵, Yikai Xu¹, Aiguo Wu⁵, Xiaoyuan Chen⁶, Zheyu Shen¹

Affiliations

¹ Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Medical Imaging Center, Nanfang Hospital, School of Biomedical Engineering, Southern Medical University, 1023 Sha-Tai South Road, Guangzhou, Guangdong 510515, China.
² State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing, 210009, China.
³ Departments of Pharmacy and Diagnostic Radiology, Faculty of Science and Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117559, Singapore.
⁴ Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
⁵ Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, 1219 Zhong-guan West Road, Ning-bo, Zhe-jiang 315201, China.
⁶ Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore 119074, Singapore.

PMID: 34738816
DOI: 10.1021/acs.nanolett.1c03130

Abstract

Hollow mesoporous organosilica nanoparticles (HMONs) are widely considered as a promising drug nanocarrier, but the loaded drugs can easily leak from HMONs, resulting in the considerably decreased drug loading capacity and increased biosafety risk. This study reports the smart use of core/shell Fe₃O₄/Gd₂O₃ (FG) hybrid nanoparticles as a gatekeeper to block the pores of HMONs, which can yield an unreported large loading content (up to 20.4%) of DOX. The conjugation of RGD dimer (R2) onto the DOX-loaded HMON with FG capping (D@HMON@FG@R2) allowed for active tumor-targeted delivery. The aggregated FG in D@HMON@FG@R2 could darken the normal tissue surrounding the tumor due to the high r₂ value (253.7 mM^-1 s^-1) and high r₂/r₁ ratio (19.13), and the intratumorally released FG as a result of reducibility-triggered HMON degradation could brighten the tumor because of the high r₁ value (20.1 mM^-1 s^-1) and low r₂/r₁ ratio (7.01), which contributed to high contrast magnetic resonance imaging (MRI) for guiding highly efficient tumor-specific DOX release and chemotherapy.

Keywords: high contrast magnetic resonance imaging; intelligent pore switch; mesoporous organosilica; reducibility-responsive degradation; tumor-specific chemotherapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Doxorubicin / pharmacology
Doxorubicin / therapeutic use
Magnetic Resonance Imaging
Nanoparticles* / therapeutic use
Phototherapy* / methods
Polymers

Substances

Polymers
Doxorubicin