Prognostic Factors of Potential Early Recurrence of Hypopharyngeal Carcinoma

Anticancer Res. 2021 Nov;41(11):5761-5766. doi: 10.21873/anticanres.15392.

Abstract

Background/aim: Prognostic factors of hypopharyngeal carcinoma have been reported previously. However, recurrent cases of this disease occurring within 6 months of treatment have been excluded or poorly documented in many studies. We aimed to evaluate the prognostic factors of hypopharyngeal carcinoma recurrence within 6 months.

Patients and methods: A total of 120 patients were eligible for this retrospective study. Recurrent cases of hypopharyngeal carcinoma occurring within 6 months of treatment were evaluated and compared with non-recurrent cases.

Results: Recurrence within 6 months was detected in 28/50 cases. In univariate analyses, classification markers (pT≥4a and cN≥2b) were statistically significant prognostic factors for early recurrence (p=0.04 and p=0.04, respectively); however, only pT≥4a was predictive of recurrence in multivariate analyses (p=0.02).

Conclusion: Risk stratification according to the prognostic factor pT≥4a will allow physicians to identify patients who should be followed meticulously within the first 6 months.

Keywords: Early recurrence; follow-up; hypopharyngeal carcinoma; prognostic factor.

MeSH terms

  • Aged
  • Disease Progression
  • Disease-Free Survival
  • Female
  • Humans
  • Hypopharyngeal Neoplasms / mortality
  • Hypopharyngeal Neoplasms / pathology*
  • Hypopharyngeal Neoplasms / therapy
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local*
  • Neoplasm Staging
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • Squamous Cell Carcinoma of Head and Neck / mortality
  • Squamous Cell Carcinoma of Head and Neck / secondary*
  • Squamous Cell Carcinoma of Head and Neck / therapy
  • Time Factors
  • Treatment Outcome