ALD coated polypropylene hernia meshes for prevention of mesh-related post-surgery complications: an experimental study in animals

Ilmutdin M Abdulagatov; Razin M Ragimov; Мagomed А Khamidov; Abay M Maksumova; Naida M Abdullaeva

doi:10.1088/1748-605X/ac361e

ALD coated polypropylene hernia meshes for prevention of mesh-related post-surgery complications: an experimental study in animals

Biomed Mater. 2021 Nov 19;17(1). doi: 10.1088/1748-605X/ac361e.

Authors

Ilmutdin M Abdulagatov^{1

2

3}, Razin M Ragimov², Мagomed А Khamidov², Abay M Maksumova¹, Naida M Abdullaeva²

Affiliations

¹ Department of Physical Chemistry, Dagestan State University, Makhachkala, Dagestan, Russia.
² Dagestan State Medical University, Makhachkala, Dagestan, Russia.
³ Dagestan State Medical University, Institute of Ecological Medicine, Makhachkala, Dagestan, Russia.

PMID: 34731849
DOI: 10.1088/1748-605X/ac361e

Abstract

In this work, thermal atomic layer deposition (ALD) was used to synthesize vanadium (V)-doped TiO₂thin nanofilm on polypropylene (PP) hernia meshes. Multiple layers of (Al₂O₃+ TiVO_x) nano-films were coated on the PP hernia mesh surface to provide a layer with a total thickness of 38 nm to improve its antibacterial properties, thereby, prevent mesh-related post-surgery complications. Highly conformal V-doped TiO₂nanofilm were deposited on PP mesh at a temperature of 85 °C. Rats and rabbits have been used to evaluate the tissue reaction on coated PP hernia meshes and biomechanical testing of the healed tissue. Five rabbits and ten rats have been implanted with ALD coated and uncoated (control) PP meshes into the back of rats and abdominal wall of rabbits. Histology of the mesh-adjacent tissues and electron microscopy of the explanted mesh surface were performed to characterize host tissue response to the implanted PP meshes. The effect of V-doped TiO₂coating on a living organism and fibroblast functions and bacterial activities were studied. The present results indicated that ALD coating improves adhesion properties and exhibited enhanced antibacterial activity compared to uncoated PP mesh. It was shown that V-doped TiO₂coatings were highly effective in inhibitingS. aureusandE. coliadhesion and exhibited excellent antibacterial activity. We found that V-doping of TiO₂, unlike bare TiO₂, allows generated and further procured strong redox reactions which effectively kills bacteria under visible light. We have reported comparative analysis of the use of undoped (bare) TiO₂and V-doped TiO₂as a coating for PP meshes and their action in biological environment and preventing biofilms formation compared with uncoated PP meshes. The PP meshes coated with V-doped TiO₂showed significantly lower shrinkage rates compared with an identical PP mesh without a coating. We have shown that ALD coatings provide non-adhesive and functional (antibacterial) properties.

Keywords: ALD; antibacterial coatings; biofilm; hernia infection; hernia repair; polypropylene mesh; titanium dioxide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abdominal Wall* / surgery
Animals
Hernia
Polypropylenes*
Prostheses and Implants
Rabbits
Rats
Surgical Mesh

Substances

Polypropylenes