A Chan-Evans-Lam approach to trisubstituted vinyl ethers

Org Biomol Chem. 2021 Nov 18;19(44):9649-9653. doi: 10.1039/d1ob01827b.

Abstract

Trisubstituted vinyl ethers were accessed via Chan-Evans-Lam coupling of vinyl trifluoroborates and primary aliphatic alcohols. This approach complements prior methods that required the use of neat liquid alcohol coupling partners. A palladium-catalyzed redox-relay Heck reaction was used to convert several vinyl ethers into aldehyde-functionalized 1,3-dihydroisobenzofurans.

Publication types

  • Research Support, Non-U.S. Gov't