The closed enriched cross maze test was employed as a new experimental model of the attention deficit disorder (ADD) for evaluation of the behavioral and neurochemical effects of the nootropic drug pantogam (100 mg/kg, intraperitoneally) and atomoxetine hydrochloride (3 mg/kg, intraperitoneally) administered subchronically to CD-1 outbred mice. Two subpopulations of rodents differed spontaneously in attention to enriched compartments (ED-Low and ED-High), were estimated on the basis of time spent by the mice in the empty or enriched compartments. The ED-Low and ED-High mice insignificantly differed in parameters associated with anxiety, exploratory efficacy and motor activity. Subchronic administration of both drugs in selected doses produced corrective effect on animal behavior seen as a selective increase in the ED-ratio values in the ED-Low subpopulation. Differences in the distribution of dopamine D2 and GABAB receptors (Bmax) between placebo-treated ED-Low and ED-High mice were found in the prefrontal cortex using the radioligand binding method. The neuroreceptor effects of atomoxetine were seen in prefrontal cortex of ED-Low mice as decrease in the Bmax values of D2 receptors by 14%. Pantogam in the prefrontal cortex of ED-Low subpopulation showed a decrease in the Bmax values of D2 receptors by 22% and an increase for GABAB receptors by 44%. Therefore, subchronic administration of pantogam had a positive corrective effect on the behavior parameters and the density of the studied receptor subtypes in animals with severe attention deficit.
Pri modelirovanii defitsita vnimaniia v teste “zakrytyĭ obogashchennyĭ krestoobraznyĭ labirint” (ZOKL) byla proizvedena otsenka povedencheskikh i neĭroretseptornykh éffektov nootropnogo sredstva pantogam (100 mg/kg/den', vnutribriushinno, v/br) i atomoksetina gidrokhlorida (3 mg/kg/den', v/br) pri ikh subkhronicheskom vvedenii autbrednym mysham CD-1. V dannom teste byli vyiavleny dve subpopuliatsii gryzunov, spontanno razlichaiushchikhsia po vnimaniiu k obogashchennym otsekam (ED-Low i ED-High), kotoroe otsenivali po prodolzhitel'nosti prebyvaniia mysheĭ v pustykh ili obogashchennykh ob"ektami otsekakh. Pokazateli, sviazannye s trevozhnost'iu, issledovatel'skoĭ i dvigatel'noĭ aktivnost'iu, v vyiavlennykh fenotipakh ne razlichalis' statisticheski dostoverno. Subkhronicheskoe vvedenie preparatov v vybrannykh dozakh privodilo k skhodnomu izbiratel'nomu deĭstviiu na povedenie zhivotnykh — uvelicheniiu znacheniĭ indeksa raspoznavaniia novykh ob"ektov (ED-ratio) v opytnykh gruppakh ED-Low (p.
Keywords: D2-receptor; GABAB-receptor; attention deficit; pantogam; prefrontal cortex.