[Effects of Intravitreal Injection of Anti-vascular Endothelial Growth Factor Drugs on Ocular Blood Vessels and Blood Flow in Patients with Diabetic Retinopathy]

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2021 Oct;43(5):796-800. doi: 10.3881/j.issn.1000-503X.12580.
[Article in Chinese]

Abstract

Diabetic retinopathy(DR)is the major microvascular disease in diabetic patients,and it is also one of the main blinding eye diseases in the current population.The typical pathological change of DR in the eyes is vascular endothelial growth factor(VEGF)-mediated neovascularization induced by retinal ischemic stimulation.Therefore,anti-VEGF drugs have gradually become one of the mainstream methods to treat DR and DR-induced diseases such as diabetic macular edema.Recent studies have proved that anti-VEGF drugs have certain effects on ocular blood vessels and blood flow in patients with DR,while the specific mechanism has not been fully elucidated.This article summarizes the research progress on the effects of intravitreal injection of anti-VEGF drugs on the ocular blood vessels and blood flow in patients with DR.

Keywords: anti-vascular endothelial growth factor drug; blood flow; blood vessel; diabetic retinopathy.

MeSH terms

  • Angiogenesis Inhibitors / therapeutic use
  • Diabetes Mellitus*
  • Diabetic Retinopathy* / drug therapy
  • Humans
  • Intravitreal Injections
  • Macular Edema* / drug therapy
  • Pharmaceutical Preparations*
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors / therapeutic use

Substances

  • Angiogenesis Inhibitors
  • Pharmaceutical Preparations
  • Vascular Endothelial Growth Factor A
  • Vascular Endothelial Growth Factors