Cerebral mucormycosis: intranasal route to deliver amphotericin B for effective management?

Curr Med Res Opin. 2022 Feb;38(2):299-301. doi: 10.1080/03007995.2021.2000779. Epub 2021 Nov 12.

Abstract

As cerebral mucormycosis is devastating in nature, here we discuss possible use of the intranasal route, in comparison to or in addition to intravenous administration, as a therapeutic approach to manage cases of mucormycosis with central nervous system involvement.

Keywords: Amphotericin B; Black fungus; Cerebral mucormycosis; Nasal inhaler; Novel treatment; Seizures.

MeSH terms

  • Amphotericin B*
  • Antifungal Agents / therapeutic use
  • Humans
  • Mucormycosis* / drug therapy

Substances

  • Antifungal Agents
  • Amphotericin B