Promising Advances in LINC01116 Related to Cancer

Yating Xu; Xiao Yu; Menggang Zhang; Qingyuan Zheng; Zongzong Sun; Yuting He; Wenzhi Guo

doi:10.3389/fcell.2021.736927

Promising Advances in LINC01116 Related to Cancer

Front Cell Dev Biol. 2021 Oct 14:9:736927. doi: 10.3389/fcell.2021.736927. eCollection 2021.

Authors

Yating Xu^{1

2

3

4}, Xiao Yu^{1

2

3

4}, Menggang Zhang^{1

2

3

4}, Qingyuan Zheng^{1

2

3

4}, Zongzong Sun⁵, Yuting He^{1

2

3

4}, Wenzhi Guo^{1

2

3

4}

Affiliations

¹ Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
² Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
³ Open and Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou, China.
⁴ Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou, China.
⁵ Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Abstract

Long non-coding RNAs (lncRNAs) are RNAs with a length of no less than 200 nucleotides that are not translated into proteins. Accumulating evidence indicates that lncRNAs are pivotal regulators of biological processes in several diseases, particularly in several malignant tumors. Long intergenic non-protein coding RNA 1116 (LINC01116) is a lncRNA, whose aberrant expression is correlated with a variety of cancers, including lung cancer, gastric cancer, colorectal cancer, glioma, and osteosarcoma. LINC01116 plays a crucial role in facilitating cell proliferation, invasion, migration, and apoptosis. In addition, numerous studies have recently suggested that LINC01116 has emerged as a novel biomarker for prognosis and therapy in malignant tumors. Consequently, we summarize the clinical significance of LINC01116 associated with biological processes in various tumors and provide a hopeful orientation to guide clinical treatment of various cancers in future studies.

Keywords: LINC01116; chemoresistance; human cancers; long non-coding RNA; prognosis.

Publication types

Review