Patient-specific Computer Simulation: An Emerging Technology for Guiding the Transcatheter Treatment of Patients with Bicuspid Aortic Valve

Cameron Dowling; Robert Gooley; Liam McCormick; Sami Firoozi; Stephen J Brecker

doi:10.15420/icr.2021.09

Patient-specific Computer Simulation: An Emerging Technology for Guiding the Transcatheter Treatment of Patients with Bicuspid Aortic Valve

Interv Cardiol. 2021 Aug 19:16:e26. doi: 10.15420/icr.2021.09. eCollection 2021 Apr.

Authors

Cameron Dowling¹, Robert Gooley¹, Liam McCormick¹, Sami Firoozi², Stephen J Brecker²

Affiliations

¹ MonashHeart, Monash Health and Monash Cardiovascular Research Centre, Monash University Melbourne, Australia.
² Cardiology Clinical Academic Group, St George's, University of London and St George's University Hospitals NHS Foundation Trust London, UK.

Abstract

Transcatheter aortic valve implantation (TAVI) is increasingly being used to treat younger, lower-risk patients, many of whom have bicuspid aortic valve (BAV). As TAVI begins to enter these younger patient cohorts, it is critical that clinical outcomes from TAVI in BAV are matched to those achieved by surgery. Therefore, the identification of patients who, on an anatomical basis, may not be suitable for TAVI, would be desirable. Furthermore, clinical outcomes of TAVI in BAV might be improved through improved transcatheter heart valve sizing and positioning. One potential solution to these challenges is patient-specific computer simulation. This review presents the methodology and clinical evidence surrounding patient-specific computer simulation of TAVI in BAV.

Keywords: Aortic valve stenosis; bicuspid aortic valve; computer simulation; finite element analysis; heart valve prosthesis implantation; transcatheter aortic valve replacement.

Publication types

Review