The Efficacy of Tripterygium Glycosides Combined with LMWH in Treatment of HSPN in Children

Yan Jin; Yanzheng Wang; Sai Wang; Qiongqiong Zhao; Donghua Zhang; Xuan Feng

doi:10.1155/2021/7223613

The Efficacy of Tripterygium Glycosides Combined with LMWH in Treatment of HSPN in Children

Evid Based Complement Alternat Med. 2021 Oct 21:2021:7223613. doi: 10.1155/2021/7223613. eCollection 2021.

Authors

Yan Jin^#¹, Yanzheng Wang^#², Sai Wang³, Qiongqiong Zhao⁴, Donghua Zhang⁵, Xuan Feng⁶

Affiliations

¹ Child Healthcare Department, Rizhao Hospital of TCM, Rizhao 276800, China.
² Department of Clinical Laboratory, Yantaishan Hospital, Yantai 264000, China.
³ Department of Critical Medicine, Affiliated Qingdao Central Hospital, Qingdao University, Qingdao 266000, China.
⁴ Department of Pediatrics, Zhangqiu District People's Hospital, Jinan 250200, China.
⁵ Tumor-Chemotherapy Department, Zhangqiu District People's Hospital, Jinan 250200, China.
⁶ Department of Outpatient, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266035, China.

^# Contributed equally.

Abstract

Objective: This study aimed to explore the clinical efficacy and relevant mechanism of Tripterygium glycosides combined with low molecular weight heparin calcium (LMWH) in the treatment of Henoch-Schönlein purpura nephritis (HSPN) in children.

Methods: 64 cases of children patients with HSPN treated at Qilu Hospital (Qingdao) from January 2015 to May 2020 were selected and randomly divided into the control group and the observation group and 32 cases in each group. Conventional medical treatment was applied in the two groups, besides which the control group was given LMWH while the observation group was given Tripterygium glycosides based on the control group. The clinical efficacy and the indexes of clinical symptoms of the two groups were compared. Immune globulin level, fibrinogen content (FIB), prothrombin time (PT), platelet level (PLT), and activated partial thromboplastin time (APTT) level of the two groups were compared before and after the treatment.

Results: The total effective rate in the observation group was significantly higher than that of the control group, and the recurrence rate in the observation group was lower than that in the control group. After treatment, urine red blood cell count and 24 h urine protein were obviously better than those of the control group. There was no statistically significant difference in PT between the two groups of children before and after treatment. The levels of PLT and FIB in the two groups of patients after treatment were significantly lower than before treatment, and the PLT levels in the observation group were lower than those in the control group.

Conclusion: The combination of Tripterygium glycosides and LMWH had good clinical effects in the treatment of children with HSPN, and it could improve the clinical symptoms, the mechanism of which might be related to the increase of PT, a decrease of PLT, and the improvement of coagulation function.