Clinical Application of Adaptive Immune Therapy in MSS Colorectal Cancer Patients

Danyang Wang; Hangyu Zhang; Tao Xiang; Gang Wang

doi:10.3389/fimmu.2021.762341

Clinical Application of Adaptive Immune Therapy in MSS Colorectal Cancer Patients

Front Immunol. 2021 Oct 13:12:762341. doi: 10.3389/fimmu.2021.762341. eCollection 2021.

Authors

Danyang Wang¹, Hangyu Zhang², Tao Xiang¹, Gang Wang³

Affiliations

¹ Department of Colorectal Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
² Department of Medical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
³ Department of Anorectal Surgery, Haiyan People's Hospital, Jiaxing, China.

Abstract

Colorectal cancer (CRC) is one of the most common cancers worldwide. However, the treatment outcomes of immunotherapy in microsatellite-stable (MSS) CRC remain unsatisfactory. As the majority of CRC cases display a molecular MSS/mismatch repair-proficient (pMMR) profile, it is particularly meaningful to explore the clinical applications of adaptive immune therapy in MSS CRC patients. In this review, we summarized the therapeutic approaches of adoptive immune therapies, including cytokines, therapeutic cancer vaccines, adoptive T-cell therapy, and immune checkpoint inhibitors, in the treatment of MSS CRCs.

Keywords: CAR-T; adaptive immune response; colorectal cancer; immune therapy; vaccines.

Publication types

Review

MeSH terms

Animals
Cancer Vaccines / therapeutic use
Colorectal Neoplasms / immunology
Colorectal Neoplasms / therapy*
Cytokines / immunology
Humans
Immune Checkpoint Inhibitors / therapeutic use
Immunotherapy*
Microsatellite Instability
Receptors, Immunologic / immunology

Substances

Cancer Vaccines
Cytokines
Immune Checkpoint Inhibitors
Receptors, Immunologic