Transdermal Photothermal Sterilization and Abscess Elimination Research of BSA-CuS Nanoparticles in vivo

ChemMedChem. 2022 Feb 4;17(3):e202100570. doi: 10.1002/cmdc.202100570. Epub 2021 Nov 10.

Abstract

The treatment of subcutaneous abscess caused by drug-resistant bacteria is facing great difficulties and receiving more attention. In this work, we employed BSA-CuS nanoparticles as a photothermal reagent to apply photothermal therapy (PTT) to combat drug-resistant bacteria in vitro and subcutaneous abscess in vivo. The BSA-CuS nanoparticles were found to be stable and biocompatible without cytotoxicity toward NIH3T3 and 4T1 cells. In vitro experiments showed that three species of drug-resistant pathogens, including Escherichia coli, Staphylococcus aureus, and Candida albicans, could be effectively sterilized under co-incubation with BSA-CuS nanoparticles and then irradiation with 1064 nm NIR laser via tissue penetration. BSA-CuS nanoparticles together with 1064 nm NIR laser irradiation could also effectively diminish subcutaneous abscesses caused by drug-resistant bacteria on mice under PTT and depth PTT without causing any serious side effects and organic damage in vivo.That is OK, thank you!

Keywords: BSA-CuS; drug-resistant pathogen; near infrared; photothermal therapy; sterilization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Candida albicans / drug effects
  • Cattle
  • Copper / chemistry
  • Copper / pharmacology*
  • Dose-Response Relationship, Drug
  • Drug Resistance, Bacterial / drug effects
  • Escherichia coli / drug effects
  • Infrared Rays
  • Mice
  • Molecular Structure
  • Nanoparticles / chemistry*
  • Photothermal Therapy
  • Serum Albumin, Bovine / chemistry*
  • Staphylococcus aureus / drug effects
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Serum Albumin, Bovine
  • Copper
  • cupric sulfide