Objectives: To systematically evaluate the effect of exercise rehabilitation on exercise capacity and quality of life in children with bronchial asthma.
Methods: PubMed, Cochrane Library, Web of Science, EBSCO, China National Knowledge Infrastructure, Weipu Data, and Wanfang Data were searched for randomized controlled trials (RCTs) on the effect of exercise rehabilitation on children with bronchial asthma published up to February 2021. RevMan 5.3 was used to perform a Meta analysis.
Results: A total of 14 studies were included, with 990 subjects in total. The Meta analysis showed that compared with the conventional treatment group, the exercise rehabilitation group had significantly better exercise capacity (distance covered in the 6-minute walk test: MD=108.13, P<0.01; rating of perceived effort: MD=-2.16, P<0.001; peak power: MD=0.94, P=0.001) and significantly higher total score of quality of life (SMD=1.28, P=0.0002), activity score (SMD=1.38, P=0.0002), symptom score (SMD=1.02, P<0.001), and emotional score (SMD=0.86, P<0.001) assessed by the Pediatric Asthma Quality of Life Questionnaire.
Conclusions: Current evidence shows that exercise rehabilitation has a positive effect in improving exercise capacity and quality of life in children with bronchial asthma. Due to limited number and quality of studies included in the analysis, further research is needed.
目的: 系统评价运动康复训练对支气管哮喘儿童运动能力和生活质量的干预效果。方法: 检索PubMed、Cochrane Library、Web of Science、EBSCO、中国知网、维普数据库、万方数据库等数据库从建库至2021年2月关于运动康复训练对支气管哮喘儿童影响的随机对照试验。采用RevMan 5.3软件进行Meta分析。结果: 共纳入14项研究，共计990例受试者。Meta分析结果显示：（1）运动康复组运动能力优于常规治疗组：6 min步行试验的步行距离（MD=108.13，P<0.01）、自我疲劳感觉值（MD=-2.16，P<0.001）、峰值功率（MD=0.94，P=0.001）均显著优于常规治疗组；（2）在儿科哮喘生活质量问卷中，运动康复组生活质量总评分（SMD=1.28，P=0.0002）显著高于常规治疗组，活动受限评分（SMD=1.38，P=0.0002）、症状评分（SMD=1.02，P<0.001）、情感功能评分（SMD=0.86，P<0.001）均显著高于常规治疗组。结论: 运动康复训练对支气管哮喘儿童运动能力和生活质量具有一定的改善作用，但受纳入研究数量和质量的限制，作为指导临床应用还需进一步研究和验证。.
Keywords: Bronchial asthma; Child; Exercise capacity; Exercise rehabilitation; Meta analysis; Quality of life.