1H-magnetic resonance spectroscopy lipoprotein profile in patients with chronic heart failure versus matched controls
Rev Esp Cardiol (Engl Ed). 2022 Nov;75(11):864-873.
doi: 10.1016/j.rec.2021.09.008.
Epub 2021 Oct 26.
[Article in
English,
Spanish]
Authors
Albert Teis
1
, Esmeralda Castelblanco
2
, Germán Cediel
3
, Nuria Amigó
4
, Josep Julve
5
, Josep Ribalta
6
, Montse Guardiola
6
, Josep Franch
7
, Marcelino Bermúdez-López
8
, Pau Codina
9
, Josep Lupón
10
, Dídac Mauricio
11
, Nuria Alonso
12
, Antoni Bayés-Genís
13
Affiliations
- 1 Institut del Cor, Departament de Cardiologia, Hospital Universitari Germans Trias, Badalona, Barcelona, Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain.
- 2 Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain; Institut de Recerca i d'Investigació Biomèdica de l'Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain; Departament d'Endocrinologia i Nutrició, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
- 3 Institut del Cor, Departament de Cardiologia, Hospital Universitari Germans Trias, Badalona, Barcelona, Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain; Institut del Cor, Unitat d'Insuficiència Cardiaca, Hospital Universitari Germans Trias, Badalona, Barcelona, Spain.
- 4 Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain; Biosfer Teslab SL, Reus, Tarragona, Spain; Departament de Ciències Mèdiques Bàsiques, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
- 5 Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain; Institut de Recerca i d'Investigació Biomèdica de l'Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain.
- 6 Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain; Unitat de Recerca en Lípids i Aterosclerosi, Departament de Medicina i Cirurgia, Universitat Rovira i Virgili, Reus, Tarragona, Spain; Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
- 7 Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain; DAP-Cat Group, Unitat de Suport a la Recerca, Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi i Gurina (IDIAPJGol), Barcelona, Spain.
- 8 Grupo Investigación Translacional Vascular y Renal, IRBLleida, Red de Investigación Renal (RedInRen-ISCIII), Lleida, Spain.
- 9 Institut del Cor, Departament de Cardiologia, Hospital Universitari Germans Trias, Badalona, Barcelona, Spain; Institut del Cor, Unitat d'Insuficiència Cardiaca, Hospital Universitari Germans Trias, Badalona, Barcelona, Spain.
- 10 Institut del Cor, Departament de Cardiologia, Hospital Universitari Germans Trias, Badalona, Barcelona, Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain; Institut del Cor, Unitat d'Insuficiència Cardiaca, Hospital Universitari Germans Trias, Badalona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain.
- 11 Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain; Institut de Recerca i d'Investigació Biomèdica de l'Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain; Institut de Recerca Biomèdica de Lleida Dr. Pifarré (IRB Lleida), Universitat de Lleida, Lleida, Spain.
- 12 Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain; Departament d'Endocrinologia i Nutrició, Hospital Universitari Germans Trias, Badalona, Barcelona, Spain. Electronic address: nalonso.germanstrias@gencat.cat.
- 13 Institut del Cor, Departament de Cardiologia, Hospital Universitari Germans Trias, Badalona, Barcelona, Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain.
Abstract
Introduction and objectives:
Advanced lipoprotein phenotyping is a better predictor of atherosclerotic cardiovascular risk than cholesterol concentration alone. Lipoprotein profiling in heart failure (HF) is incompletely characterized. We aimed to describe the lipoprotein profile in patients with chronic HF compared with a matched control population.
Methods:
This cross-sectional study was performed from May 2006 to April 2014 and included ambulatory patients with chronic HF. Lipid concentrations and the size of main lipoprotein fractions (high-density lipoprotein [HDL], low-density lipoprotein [LDL], and very low-density lipoprotein) and the particle concentration of their 3 subfractions (large, medium and small) were assessed using 1H magnetic resonance spectroscopy.
Results:
The 429 included patients with chronic HF were compared with 428 matched controls. Patients with chronic HF had lower total cholesterol and lower mean LDL (1115 vs 1352 nmol/L; P<.001) and HDL (25.7 vs 27.9μmol/L; P <.001) particle concentrations, with this last difference being mediated by a significantly lower concentration of the small subfraction of HDL (15.2 vs 18.6μmol/L; P <.001). Mean very low-density lipoprotein, LDL, and HDL particle size was significantly higher in patients with HF vs controls. All HDL-related differences from controls persisted after adjustment for New York Heart Association functional class or body mass index. We found strong negative correlations of known cardiac biomarkers (N-terminal pro-brain natriuretic peptide and interleukin-1 receptor-like 1) with total and small LDL and HDL fractions and HDL particle size.
Conclusions:
Patients with chronic HF significantly differ in their lipoprotein profile compared with unaffected controls. Further research is needed to better understand the pathogenic relevance of this difference.
Keywords:
Cholesterol; Colesterol; Espectroscopia resonancia magnética; HDL; Heart Failure; Insuficiencia cardiaca; Lipoproteins; Lipoproteínas; Magnetic resonance spectroscopy; Particles; Partículas.
Copyright © 2021 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.
MeSH terms
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Cholesterol
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Chronic Disease
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Cross-Sectional Studies
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Heart Failure* / diagnosis
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Humans
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Lipoproteins*
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Lipoproteins, LDL
Substances
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Lipoproteins
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Lipoproteins, LDL
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Cholesterol