What are the full extent and long-term effects of land dispossession and forced migration for Indigenous peoples in North America? We leveraged a new dataset of Indigenous land dispossession and forced migration to statistically compare features of historical tribal lands to present-day tribal lands at the aggregate and individual tribe level. Results show a near-total aggregate reduction of Indigenous land density and spread. Indigenous peoples were forced to lands that are more exposed to climate change risks and hazards and are less likely to lie over valuable subsurface oil and gas resources. Agricultural suitability and federal land proximity results—which affect Indigenous movements, management, and traditional uses—are mixed. These findings have substantial policy implications related to heightened climate vulnerability, extensive land reduction, and diminished land value.