Synthesis, self-aggregation and cryopreservation effects of perylene bisimide-glycopeptide conjugates

Xu He; Bing Hu; Yan Yang; Hong-Yu Zhu; Rui-Xue Rong; Xiao-Liu Li; Ke-Rang Wang

doi:10.1039/d1cc03835d

Synthesis, self-aggregation and cryopreservation effects of perylene bisimide-glycopeptide conjugates

Chem Commun (Camb). 2021 Nov 11;57(90):12000-12003. doi: 10.1039/d1cc03835d.

Authors

Xu He^{1

2}, Bing Hu^{1

2}, Yan Yang^{2

3}, Hong-Yu Zhu^{1

2}, Rui-Xue Rong^{2

3}, Xiao-Liu Li^{1

2}, Ke-Rang Wang^{1

2}

Affiliations

¹ College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, P. R. China. kerangwang@hbu.edu.cn.
² Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Hebei University), Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, Baoding, 071002, P. R. China.
³ Department of Immunology, School of Basic Medical Science, Hebei University, Baoding 071002, P. R. China.

PMID: 34709255
DOI: 10.1039/d1cc03835d

Abstract

Three perylene bisimide-glycopeptide conjugates (PBI-AFF-Man, PBI-AFF-Glu and PBI-AFF-Gal) were synthesized, which showed moderate activity in the control of ice crystal growth. Furthermore, the cellular cryopreservation effects of PBI-AFF-Man, PBI-AFF-Glu and PBI-AFF-Gal showed enhancements in cell viabilities, especially for PBI-AFF-Glu with values of 22.77 ± 3.33% (HeLa cells), 19.43 ± 1.90% (A549 cells) and 16.63 ± 1.76% (GES-1 cells) at a dose of 1.0 mg mL^-1. This work will help guide the development of self-assembled cryoprotectants.