The insecticides permethrin and chlorpyrifos show limited genotoxicity and no leukemogenic potential in human and murine hematopoietic stem progenitor cells

Virginia C Rodriguez-Cortez; Maria Pilar Navarrete-Meneses; Oscar Molina; Talia Velasco-Hernandez; Jessica Gonzalez; Paola Romecin; Francisco Gutierrez-Aguera; Heleia Roca-Ho; Meritxell Vinyoles; Eric Kowarz; Pedro Marin; Sandra Rodriguez-Perales; Carlos Gomez-Marin; Patricia Perez-Vera; Felipe Cortes-Ledesma; Anna Bigas; Andrea Terron; Clara Bueno; Pablo Menendez

doi:10.3324/haematol.2021.279047

The insecticides permethrin and chlorpyrifos show limited genotoxicity and no leukemogenic potential in human and murine hematopoietic stem progenitor cells

Haematologica. 2022 Feb 1;107(2):544-549. doi: 10.3324/haematol.2021.279047.

Authors

Virginia C Rodriguez-Cortez¹, Maria Pilar Navarrete-Meneses², Oscar Molina³, Talia Velasco-Hernandez³, Jessica Gonzalez⁴, Paola Romecin³, Francisco Gutierrez-Aguera³, Heleia Roca-Ho³, Meritxell Vinyoles³, Eric Kowarz⁵, Pedro Marin⁶, Sandra Rodriguez-Perales⁷, Carlos Gomez-Marin⁸, Patricia Perez-Vera², Felipe Cortes-Ledesma⁸, Anna Bigas⁹, Andrea Terron¹⁰, Clara Bueno¹¹, Pablo Menendez¹²

Affiliations

¹ Josep Carreras Leukemia Research Institute. Department of Biomedicine. School of Medicine, University of Barcelona. Barcelona. vrodriguez@carrerasresearch.org.
² Laboratorio de Genetica y Cancer, Departamento de Genetica Humana, Instituto Nacional de Pediatria, Ciudad de Mexico.
³ Josep Carreras Leukemia Research Institute. Department of Biomedicine. School of Medicine, University of Barcelona. Barcelona.
⁴ Cancer Research Program, Institut Hospital del Mar d'Investigacions Mediques, Hospital del Mar, Barcelona.
⁵ Institute of Pharmaceutical Biology/DCAL, Goethe-University of Frankfurt, Biocenter, Max-von-Laue-Str. 9, D-60438, Frankfurt/Main.
⁶ Hematology Department. Hospital Clinic de Barcelona.
⁷ Molecular Cytogenetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Center (CNIO), Madrid.
⁸ Topology and DNA breaks Group, Spanish National Cancer Center (CNIO), Madrid.
⁹ Josep Carreras Leukemia Research Institute. Department of Biomedicine. School of Medicine, University of Barcelona. Barcelona, Spain; Cancer Research Program, Institut Hospital del Mar d'Investigacions Mediques, Hospital del Mar, Barcelona, Spain; Centro de Investigacion Biomedica en Red-Oncologia (CIBERONC).
¹⁰ European Food and Safety Authority. Parma.
¹¹ Josep Carreras Leukemia Research Institute. Department of Biomedicine. School of Medicine, University of Barcelona. Barcelona, Spain; Centro de Investigacion Biomedica en Red-Oncologia (CIBERONC).
¹² Josep Carreras Leukemia Research Institute. Department of Biomedicine. School of Medicine, University of Barcelona. Barcelona, Spain; Centro de Investigacion Biomedica en Red-Oncologia (CIBERONC); Institucio Catalana de Recerca i Estudis Avancats (ICREA), Barcelona. pmenendez@carrerasresearch.org.

No abstract available

MeSH terms

Animals
Chlorpyrifos* / toxicity
Hematopoietic Stem Cells
Humans
Insecticides* / toxicity
Mice
Permethrin / toxicity

Substances

Insecticides
Permethrin
Chlorpyrifos

Grants and funding

Funding: this work was supported by CERCA/Generalitat de Catalunya and Fundació Josep Carreras-Obra Social la Caixa through institutional support. Pablo Menendez’s laboratory was supported by the Spanish Ministry of Science and Innovation (PID2019-108160RB-I00 / AEI / 10.13039/501100011033), Retos Colaboración with Banc de Sang i Teixits (RTC-2017-6367-1), the European Food and Safety Authority (EFSA.PRAS.2018.04-CT1), and the European Research Council. VR-C and MV were supported by Juan de la Cierva fellowships from the Spanish Ministry of Science and Innovation (FJCI-2015-24303 and IJCI-2017-33172). CB was supported by the Health Institute Carlos III (ISCIII/FEDER PI17/01028 and PI20/00822). PP-V and PN-M were supported by Consejo Nacional de Ciencia y Tecnología (CB-2012-01-183467) and by Fondos del Presupuesto Federal para la Investigación (project 001/2013, Instituto Nacional de Pediatría). JG was supported by Centro de Investigación Biomédica en Red en Cáncer (PID2019-104695RBI00). TV-H was supported by a Maria Sklodowska-Marie Curie fellowship (792923). OM was supported by a Beatriu de Pinós postdoctoral fellowship (BP2016-00048) from the Generalitat de Catalunya, a Lady Tata award from the Lady Tata Memorial Trust, and an investigator fellowship from the Spanish Cancer Research Association (AECC INVES211226MOLI). SR-P is supported by grants from the Spanish National Research and Development Plan, Instituto de Salud Carlos III, and FEDER (PI17/02303, PI20/01837 and DTS19/00111); AEI/MICIU EXPLORA Project BIO2017-91272-EXP and AECC_Lab_2020 Project. PM is an investigator of the Spanish Cell Therapy cooperative network (TERCEL).