Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water

Chem Commun (Camb). 2021 Nov 9;57(89):11847-11850. doi: 10.1039/d1cc04774d.

Abstract

Bio-catalytic reactions involving ene-reductases (EREDs) in tandem with chemo-catalysis in water can be greatly enhanced by the presence of nanomicelles derived from the surfactant TPGS-750-M. Transformations are provided that illustrate the variety of sequences now possible in 1-pot as representative examples of this environmentally attractive approach to organic synthesis.

MeSH terms

  • Alkenes / chemistry*
  • Biocatalysis
  • Micelles*
  • NADH, NADPH Oxidoreductases / chemistry*
  • Oxidation-Reduction
  • Polyethylene Glycols / chemistry
  • Surface-Active Agents / chemistry
  • Vitamin E / analogs & derivatives
  • Water / chemistry

Substances

  • Alkenes
  • Micelles
  • Surface-Active Agents
  • Water
  • Vitamin E
  • Polyethylene Glycols
  • NADH, NADPH Oxidoreductases