Lanostane triterpenoids from the fruiting bodies of Fomitopsis pinicola and their anti-inflammatory activities

Yushuang Liu; Wei Liu; Miaomiao Li; Tao Yuan

doi:10.1016/j.phytochem.2021.112985

Lanostane triterpenoids from the fruiting bodies of Fomitopsis pinicola and their anti-inflammatory activities

Phytochemistry. 2022 Jan:193:112985. doi: 10.1016/j.phytochem.2021.112985. Epub 2021 Oct 22.

Authors

Yushuang Liu¹, Wei Liu², Miaomiao Li³, Tao Yuan⁴

Affiliations

¹ The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang, 330022, China; Key Laboratory of Plant Resources and Chemistry of Arid Zone, State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, China.
² The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang, 330022, China; Key Laboratory of Plant Resources and Chemistry of Arid Zone, State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China.
³ The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang, 330022, China.
⁴ The Laboratory of Effective Substances of Jiangxi Genuine Medicinal Materials, College of Life Sciences, Jiangxi Normal University, Nanchang, 330022, China; Key Laboratory of Plant Resources and Chemistry of Arid Zone, State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China. Electronic address: tyuan@jxnu.edu.cn.

PMID: 34695707
DOI: 10.1016/j.phytochem.2021.112985

Abstract

Thirteen previously undescribed lanostane triterpenoids, as well as nine known lanostane triterpenoids, were isolated from the fruiting bodies of Fomitopsis pinicola (Sw.) P. Karst. Their structures and absolute configurations were characterized by extensive analysis of spectroscopic data and single-crystal X-ray diffraction. Nor-pinicolic acids A-F possess unusual C-25-C-27 nor-lanostane skeletons, which were first reported from F. pinicola. Anti-inflammatory assays indicated that pinicopsic acid F and 16α-hydroxy-3-oxolanosta-7,9(11),24-trien-21-oic acid showed moderate inhibitory activities against LPS-induced NO production in RAW 264.7 cells, with IC₅₀ values of 24.5 and 25.7 μM, respectively.

Keywords: Anti-inflammatory; Fomitopsis pinicola; Lanostane triterpenoid; Polyporaceae.

MeSH terms

Anti-Inflammatory Agents / pharmacology
Coriolaceae
Fruiting Bodies, Fungal
Molecular Structure
Triterpenes* / pharmacology

Substances

Anti-Inflammatory Agents
Triterpenes

Supplementary concepts

Fomitopsis pinicola