Methotrexate-Induced Septicemia With Severe Pancytopenia and Diffuse Cutaneous Ulcerative Lesions

Iadarilang Tiewsoh; Biswajit Dey; Mary Chhangte; Monaliza Lyngdoh; Varsha Sathees

doi:10.7759/cureus.18069

Methotrexate-Induced Septicemia With Severe Pancytopenia and Diffuse Cutaneous Ulcerative Lesions

Cureus. 2021 Sep 17;13(9):e18069. doi: 10.7759/cureus.18069. eCollection 2021 Sep.

Authors

Iadarilang Tiewsoh¹, Biswajit Dey², Mary Chhangte³, Monaliza Lyngdoh⁴, Varsha Sathees⁴

Affiliations

¹ General Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.
² Pathology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.
³ Dermatology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.
⁴ Internal Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.

Abstract

Methotrexate, a folate antimetabolite and one of the first few anti-neoplastic drugs, is now a commonly used drug in the treatment of many inflammatory disorders ranging from diseases like rheumatoid arthritis to psoriasis. The life-threatening toxicity of methotrexate in inflammatory diseases is not commonly encountered. Here we report a case of life-threatening multiorgan failure from methotrexate toxicity, which was given for skin lesions suspected to be psoriasis.

Keywords: methotrexate; pancytopenia; psoriasis; septicemia; toxicity; ulcerative lesions.

Publication types

Case Reports