Wearable skin-like optoelectronic systems with suppression of motion artifacts for cuff-less continuous blood pressure monitor

Haicheng Li; Yinji Ma; Ziwei Liang; Zhouheng Wang; Yu Cao; Yuan Xu; Hua Zhou; Bingwei Lu; Ying Chen; Zhiyuan Han; Shisheng Cai; Xue Feng

doi:10.1093/nsr/nwaa022

Wearable skin-like optoelectronic systems with suppression of motion artifacts for cuff-less continuous blood pressure monitor

Natl Sci Rev. 2020 May;7(5):849-862. doi: 10.1093/nsr/nwaa022. Epub 2020 Feb 14.

Authors

Haicheng Li^{1

2}, Yinji Ma^{1

2}, Ziwei Liang^{1

2}, Zhouheng Wang^{1

2}, Yu Cao^{1

2}, Yuan Xu³, Hua Zhou³, Bingwei Lu^{1

2}, Ying Chen⁴, Zhiyuan Han^{1

2}, Shisheng Cai^{1

2}, Xue Feng^{1

2}

Affiliations

¹ Key Laboratory of Applied Mechanics, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China.
² Center for Flexible Electronics Technology, Tsinghua University, Beijing 100084, China.
³ Intensive Care Unit, Beijing Tsinghua Changgung Hospital, Beijing 102218, China.
⁴ Institute of Flexible Electronics Technology of Tsinghua University, Jiaxing 314000, China.

Abstract

According to the statistics of the World Health Organization, an estimated 17.9 million people die from cardiovascular diseases each year, representing 31% of all global deaths. Continuous non-invasive arterial pressure (CNAP) is essential for the management of cardiovascular diseases. However, it is difficult to achieve long-term CNAP monitoring with the daily use of current devices due to irritation of the skin as well as the lack of motion artifacts suppression. Here, we report a high-performance skin-like optoelectronic system integrated with ultra-thin flexible circuits to monitor CNAP. We introduce a theoretical model via the virtual work principle for predicting the precise blood pressure and suppressing motion artifacts, and propose optical difference in the frequency domain for stable optical measurements in terms of skin-like devices. We compare the results with the blood pressure acquired by invasive (intra-arterial) blood pressure monitoring for >1500 min in total on 44 subjects in an intensive care unit. The maximum absolute errors of diastolic and systolic blood pressure were ±7/±10 mm Hg, respectively, in immobilized, and ±10/±14 mm Hg, respectively, in walking scenarios. These strategies provide advanced blood pressure monitoring techniques, which would directly address an unmet clinical need or daily use for a highly vulnerable population.

Keywords: blood pressure monitor; optical measurement; optoelectronics; skin-like devices.