Sirtuin 1 in Endothelial Dysfunction and Cardiovascular Aging

Stefano Ministrini; Yustina M Puspitasari; Georgia Beer; Luca Liberale; Fabrizio Montecucco; Giovanni G Camici

doi:10.3389/fphys.2021.733696

Sirtuin 1 in Endothelial Dysfunction and Cardiovascular Aging

Front Physiol. 2021 Oct 6:12:733696. doi: 10.3389/fphys.2021.733696. eCollection 2021.

Authors

Stefano Ministrini^{1

2}, Yustina M Puspitasari¹, Georgia Beer¹, Luca Liberale^{1

3}, Fabrizio Montecucco^{3

4}, Giovanni G Camici^{1

5

6}

Affiliations

¹ Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland.
² Internal Medicine, Angiology and Atherosclerosis, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
³ First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy.
⁴ Istituto di Ricerca e Cura a Carattere Scientifico Ospedale Policlinico San Martino Genoa-Italian Cardiovascular Network, Genoa, Italy.
⁵ Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland.
⁶ Department of Research and Education, University Hospital Zurich, Zurich, Switzerland.

Abstract

Sirtuin 1 (SIRT1) is a histone deacetylase belonging to the family of Sirtuins, a class of nicotinamide adenine dinucleotide (NAD+)-dependent enzymes with multiple metabolic functions. SIRT1 localizes in the nucleus and cytoplasm, and is implicated in the regulation of cell survival in response to several stimuli, including metabolic ones. The expression of SIRT1 is associated with lifespan and is reduced with aging both in animal models and in humans, where the lack of SIRT1 is regarded as a potential mediator of age-related cardiovascular diseases. In this review, we will summarize the extensive evidence linking SIRT1 functional and quantitative defects to cellular senescence and aging, with particular regard to their role in determining endothelial dysfunction and consequent cardiovascular diseases. Ultimately, we outline the translational perspectives for this topic, in order to highlight the missing evidence and the future research steps.

Keywords: aging–old age–seniors; atherosclerosis; cardiovascular disease; eNOS (endothelial nitric oxide synthase); endothelial (dys)function; inflammaging; sirtuin (SIRT1).

Publication types

Review