The HO-1/CO System and Mitochondrial Quality Control in Skeletal Muscle

Exerc Sport Sci Rev. 2022 Jan 1;50(1):49-55. doi: 10.1249/JES.0000000000000277.

Abstract

Inducible heme oxygenase (HO)-1 catalyzes the breakdown of heme to biliverdin, iron, and carbon monoxide (CO). CO binds to cytochrome c oxidase and alters mitochondrial redox balance and coordinately regulates mitochondrial quality control (MQC) during oxidant stress and inflammation. The hypothesis presented is that the skeletal muscle HO-1/CO system helps modulate components in the MQC cycle during metabolic stress.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Carbon Monoxide*
  • Humans
  • Inflammation
  • Muscle, Skeletal*
  • Stress, Physiological

Substances

  • Carbon Monoxide