The effects of treadmill exercise in animal models of Parkinson's disease: A systematic review

Ana Flávia F Ferreira; Karina Henrique Binda; Caroline Cristiano Real

doi:10.1016/j.neubiorev.2021.10.019

The effects of treadmill exercise in animal models of Parkinson's disease: A systematic review

Neurosci Biobehav Rev. 2021 Dec:131:1056-1075. doi: 10.1016/j.neubiorev.2021.10.019. Epub 2021 Oct 21.

Authors

Ana Flávia F Ferreira¹, Karina Henrique Binda², Caroline Cristiano Real³

Affiliations

¹ Laboratory of Cellular Neurobiology, Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.
² Laboratory of Functional Neuroanatomy of Pain, Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil; Translational Neuropsychiatry Unit (TNU), Aarhus University, Aarhus, Denmark.
³ Translational Neuropsychiatry Unit (TNU), Aarhus University, Aarhus, Denmark; Faculdade de Medicina (FMUSP), Universidade de Sao Paulo, Sao Paulo, SP, Brazil. Electronic address: caroline.real@fm.usp.br.

PMID: 34688727
DOI: 10.1016/j.neubiorev.2021.10.019

Abstract

Parkinson's disease (PD) is a progressive disabling brain disorder. Physical exercise has been shown to alleviate the symptoms of PD and, consequently, improve patient quality of life. Exercise mechanisms involved in beneficial effects on PD have been widely investigated. This study aims to systematically review the literature on the use of treadmill exercise in PD animal models. The study was conducted according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). Searches were conducted in MEDLINE, EMBASE, and ISI databases. In total, 78 studies were included. The dopaminergic system, behavior, neuroplasticity, neuroinflammation, mitochondria, and musculoskeletal systems were some of the outcomes evaluated by the selected studies. Based on the systematic review center for laboratory animal experimentation (SYRCLE) RoB tool, the methodologies revealed a high risk of bias and lack of information about study design, which needs attention for data reproducibility. This review can guide future studies that aim to fill existing gaps regarding the effects of treadmill exercise in PD animal models.

Keywords: Dopaminergic system; Neuroplasticity; Neuroprotection; Parkinson’s disease animal model; Treadmill exercise.

Publication types

Research Support, Non-U.S. Gov't
Review
Systematic Review

MeSH terms

Animals
Disease Models, Animal
Exercise
Humans
Parkinson Disease*
Quality of Life
Reproducibility of Results