The Microenvironment's Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications

Alessandro Pileri; Alba Guglielmo; Vieri Grandi; Silvia Alberti Violetti; Daniele Fanoni; Paolo Fava; Claudio Agostinelli; Emilio Berti; Pietro Quaglino; Nicola Pimpinelli

doi:10.3390/cells10102780

The Microenvironment's Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications

Cells. 2021 Oct 17;10(10):2780. doi: 10.3390/cells10102780.

Authors

Affiliations

¹ Dermatology, IRCCS, S. Orsola-Malpighi Polyclinic, 40100 Bologna, Italy.
² Department of Specialistic, Diagnostic and Experimental Medicine (DIMES), Alma Mater Studiorum, University of Bologna, 40100 Bologna, Italy.
³ Section of Dermatology, Department of Health Sciences, University of Florence, 20019 Florence, Italy.
⁴ UOC Dermatologia, Fondazione Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
⁵ Dermatologic Clinic, University of Turin Medical School, 10092 Turin, Italy.
⁶ Hematopathology, IRCCS, S. Orsola-Malpighi Polyclinic, 40100 Bologna, Italy.

Abstract

Background: Mycosis fungoides (MF) and Sezary Syndrome (SS) are the most common cutaneous T-cell lymphomas. It has been hypothesized that the interaction between the immune system, cutaneous cells, and neoplastic elements may play a role in MF/SS pathogenesis and progression.

Methods: This paper aims to revise in a narrative way our current knowledge of the microenvironment's role in MF/SS.

Results and conclusions: Literature data support a possible implication of microenvironment cells in MF/SS pathogenesis and progression, opening up new therapeutic avenues.

Keywords: Sezary syndrome; cutaneous; cutaneous T-cell lymphomas (CTCLs); lymphomas.

Publication types

Review

MeSH terms

Animals
Disease Progression*
Humans
Mycosis Fungoides / pathology*
Mycosis Fungoides / therapy*
Sezary Syndrome / pathology*
Sezary Syndrome / therapy*
Skin Neoplasms / pathology*
Skin Neoplasms / therapy*
Tumor Microenvironment*