Rhytidhylides A and B, Two New Phthalide Derivatives from the Endophytic Fungus Rhytidhysteron sp. BZM-9

Sha Zhang; Dekun Chen; Min Kuang; Weiwei Peng; Yan Chen; Jianbing Tan; Fenghua Kang; Kangping Xu; Zhenxing Zou

doi:10.3390/molecules26206092

Rhytidhylides A and B, Two New Phthalide Derivatives from the Endophytic Fungus Rhytidhysteron sp. BZM-9

Molecules. 2021 Oct 9;26(20):6092. doi: 10.3390/molecules26206092.

Authors

Sha Zhang^{1

2}, Dekun Chen^{1

2}, Min Kuang^{1

2}, Weiwei Peng^{1

2}, Yan Chen^{1

2}, Jianbing Tan^{1

2}, Fenghua Kang^{1

2}, Kangping Xu^{1

2}, Zhenxing Zou^{1

2}

Affiliations

¹ Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
² Hunan Key Laboratory of Diagnostic and Therapeutic Drug Research for Chronic Diseases, Changsha 410013, China.

Abstract

Two new phthalide derivatives, rhytidhylides A (1) and B (2), together with ten known compounds (3-12) were isolated from cultures of Rhytidhysteron sp. BZM-9, an endophyte isolated from the leaves of Leptospermum brachyandrum. Their structures were identified by an extensive analysis of NMR, HRESIMS, ECD, and through comparison with data reported in the literature. In addition, the cytotoxic activities against two human hepatoma cell lines (HepG2 and SMMC7721) and antibacterial activities against MRSA and E. coli were evaluated.

Keywords: Leptospermum brachyandrum; Rhytidhysteron sp. BZM-9; endophyte; phthalate derivative.

MeSH terms

Ascomycota / chemistry*
Benzofurans / adverse effects
Benzofurans / isolation & purification*
Benzofurans / pharmacology
Cell Line, Tumor / drug effects
Endophytes / chemistry
Escherichia coli / drug effects
Humans
Leptospermum / microbiology
Molecular Structure

Substances

Benzofurans
phthalide

Abstract

MeSH terms

Substances

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