Pre-Exposure Prophylaxis (PrEP) Adherence Questionnaire: Psychometric Validation among Sexually Transmitted Infection Patients in China

Int J Environ Res Public Health. 2021 Oct 19;18(20):10980. doi: 10.3390/ijerph182010980.

Abstract

Background: Ensuring adherence guarantees the efficacy of pre-exposure prophylaxis (PrEP).

Methods: We conducted a cross-sectional study among 816 sexually transmitted infection (STI) patients in Shanghai. The questionnaire included self-reported demographic characteristics, self-administered items on adherence to free oral PrEP, and PrEP uptake behavior measurement. We conducted item analysis, reliability analysis, validity analysis and receiver operating characteristic (ROC) curve analysis.

Results: Not all items were considered acceptable in the item analysis. The questionnaire had a McDonald's ω coefficient of 0.847. The scale-level content validity index (CVI) was 0.938 and the item-level CVI of each item ranged from 0.750 to 1. In exploratory factor analysis, we introduced a four-factor model accounting for 79.838% of the aggregate variance, which was validated in confirmatory factor analysis. Adding PrEP adherence questionnaire scores contributed to prediction of PrEP uptake behavior (p < 0.001) in regression analysis. The maximum area under the ROC curve was 0.778 (95% IC: 0.739-0.817).

Conclusion: The PrEP adherence questionnaire presented psychometric validation among STI patients.

Keywords: HIV prevention; adherence; pre-exposure prophylaxis (PrEP); questionnaire.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents*
  • China
  • Cross-Sectional Studies
  • HIV Infections*
  • Homosexuality, Male
  • Humans
  • Male
  • Medication Adherence
  • Pre-Exposure Prophylaxis*
  • Psychometrics
  • Reproducibility of Results
  • Sexually Transmitted Diseases* / prevention & control
  • Surveys and Questionnaires

Substances

  • Anti-HIV Agents