Controlled Release of Doxorubicin for Targeted Chemo-Photothermal Therapy in Breast Cancer HS578T Cells Using Albumin Modified Hybrid Nanocarriers

Int J Mol Sci. 2021 Oct 18;22(20):11228. doi: 10.3390/ijms222011228.

Abstract

Hybrid nanomaterials have attracted research interest owing to their intriguing properties, which may offer new diagnostic options with triggering features, able to realize a new kind of tunable nanotherapeutics. Hybrid silica/melanin nanoparticles (NPs) containing silver seeds (Me-laSil_Ag-HSA NPs) disclosed relevant photoacoustic contrast for molecular imaging. In this study we explored therapeutic function in the same nanoplatform. For this purpose, MelaSil_Ag-HSA were loaded with doxorubicin (DOX) (MelaSil_Ag-HSA@DOX) and tested to assess the efficiency of drug delivery combined with concurrent photothermal treatment. The excellent photothermal properties allowed enhanced cytotoxic activity at significantly lower doses than neat chemotherapeutic treatment. The results revealed that MelaSil_Ag-HSA@DOX is a promising platform for an integrated photothermal (PT) chemotherapy approach, reducing the efficacy concentration of the DOX and, thus, potentially limiting the several adverse side effects of the drug in in vivo treatments.

Keywords: PTT; breast cancer; doxorubicin; drug delivery; hybrid nanoparticles; melanin nanoparticles; photothermal.

MeSH terms

  • Albumins / chemistry*
  • Antibiotics, Antineoplastic / pharmacology
  • Apoptosis
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Breast Neoplasms / therapy*
  • Cell Proliferation
  • Combined Modality Therapy
  • Doxorubicin / pharmacology*
  • Drug Carriers / chemistry*
  • Drug Delivery Systems*
  • Drug Liberation
  • Female
  • Humans
  • Infrared Rays
  • Nanoparticles / administration & dosage*
  • Nanoparticles / chemistry
  • Photothermal Therapy / methods*
  • Tumor Cells, Cultured

Substances

  • Albumins
  • Antibiotics, Antineoplastic
  • Drug Carriers
  • Doxorubicin