A Review of THz Technologies for Rapid Sensing and Detection of Viruses including SARS-CoV-2

Biosensors (Basel). 2021 Sep 22;11(10):349. doi: 10.3390/bios11100349.

Abstract

Virus epidemics such as Ebola virus, Zika virus, MERS-coronavirus, and others have wreaked havoc on humanity in the last decade. In addition, a coronavirus (SARS-CoV-2) pandemic and its continuously evolving mutants have become so deadly that they have forced the entire technical advancement of healthcare into peril. Traditional ways of detecting these viruses have been successful to some extent, but they are costly, time-consuming, and require specialized human resources. Terahertz-based biosensors have the potential to lead the way for low-cost, non-invasive, and rapid virus detection. This review explores the latest progresses in terahertz technology-based biosensors for the virus, viral particle, and antigen detection, as well as upcoming research directions in the field.

Keywords: SARS-CoV-2; biosensing; immunobiosensing; metasenors; plasmonics; terahertz.

Publication types

  • Review

MeSH terms

  • Antigens, Viral / analysis
  • Biosensing Techniques / methods*
  • COVID-19 / diagnosis*
  • COVID-19 / virology
  • Humans
  • Immunoassay
  • RNA, Viral / analysis
  • SARS-CoV-2 / genetics
  • SARS-CoV-2 / isolation & purification
  • SARS-CoV-2 / metabolism*
  • Terahertz Spectroscopy

Substances

  • Antigens, Viral
  • RNA, Viral