Nanostructured lipid carriers for the encapsulation of phloretin: preparation and in vitro characterization studies

Liyuan Gu; Rui Sun; Wenjuan Wang; Qiang Xia

doi:10.1016/j.chemphyslip.2021.105150

Nanostructured lipid carriers for the encapsulation of phloretin: preparation and in vitro characterization studies

Chem Phys Lipids. 2022 Jan:242:105150. doi: 10.1016/j.chemphyslip.2021.105150. Epub 2021 Oct 19.

Authors

Liyuan Gu¹, Rui Sun¹, Wenjuan Wang¹, Qiang Xia²

Affiliations

¹ School of Biological Science and Medical Engineering, State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China; National Demonstration Center for Experimental Biomedical Engineering Education, Southeast University, Nanjing 210096, China; Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou 215123, China.
² School of Biological Science and Medical Engineering, State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China; National Demonstration Center for Experimental Biomedical Engineering Education, Southeast University, Nanjing 210096, China; Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou 215123, China. Electronic address: xiaq@seu.edu.cn.

PMID: 34673008
DOI: 10.1016/j.chemphyslip.2021.105150

Abstract

Phloretin is a powerful antioxidant with many effects, such as anti-cancer, anti-inflammatory, promoting cell renewal, delaying aging and so on. However, the application of phloretin was limited by its low water solubility, low absorption in vivo and unstable properties. A phloretin-loaded nanostructured lipid carrier was designed with a high-pressure homogenization technique. The mean particle size of phloretin NLC was 137.40 ± 3.27 nm, and the Polydispersity index (PdI) value was 0.237 ± 0.005. The encapsulation efficiency was 96.68% ± 0.06%. Transmission electron microscopy images showed that the phloretin-loaded nanostructured lipid carriers were spherical. Phloretin in NLC showed a sustained release pattern in vitro. The results showed that phloretin NLC is more suitable for absorption than phloretin ethanol solution, and NLC can be a promising carrier for phloretin in the food industry.

Keywords: Antioxidant activity; Digestion behavior; Nanostructured lipid carrier; Phloretin; Sustained release.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Carriers*
Lipids
Nanostructures*
Particle Size
Phloretin

Substances

Drug Carriers
Lipids
Phloretin