Abstract
Background:
The serum and glucocorticoid-induced kinase-1 (SGK1) belonging to the AGC protein kinase family phosphorylates serine and threonine residues of target proteins. It regulates numerous ion channels and transporters and promotes survival under cellular stress. Unique to SGK1 is a tight control at transcriptional and post-transcriptional levels. SGK1 regulates multiple signal transduction pathways related to tumor development. Several studies have reported that SGK1 is upregulated in different types of human malignancies and induces resistance against inhibitors, drugs, and targeted therapies.
Results and conclusion:
This review highlights the cellular functions of SGK1, its crucial role in cancer development, and clinical insights for SGK1 targeted therapies. Furthermore, the role of SGK1-mediated autophagy as a potential therapeutic target for cancer has been discussed.
Keywords:
Autophagy; Cancer; Inhibitors; SGK1; Tumorigenesis.
© 2021. The Author(s), under exclusive licence to Springer Nature B.V.
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents / therapeutic use*
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Autophagy / drug effects*
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Biomarkers, Tumor / antagonists & inhibitors
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Biomarkers, Tumor / metabolism
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Carcinogenesis / drug effects
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Carcinogenesis / genetics
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Carcinogenesis / metabolism*
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Gene Expression Regulation, Neoplastic
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Genes, Tumor Suppressor
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Humans
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Immediate-Early Proteins / antagonists & inhibitors
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Immediate-Early Proteins / genetics
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Immediate-Early Proteins / metabolism*
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Molecular Targeted Therapy / methods*
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Neoplasms / diagnosis
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Neoplasms / drug therapy*
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Neoplasms / genetics
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Neoplasms / metabolism*
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Oncogenes
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Protein Serine-Threonine Kinases / antagonists & inhibitors
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / metabolism*
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Signal Transduction / drug effects*
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Transcriptional Activation
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Tumor Microenvironment / drug effects
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Tumor Microenvironment / genetics
Substances
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Antineoplastic Agents
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Biomarkers, Tumor
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Immediate-Early Proteins
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Protein Serine-Threonine Kinases
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serum-glucocorticoid regulated kinase