Abstract
TNBC: triple negative breast cancer; ROS: reactive oxygen species; NAC: N-acetyl-L-cysteine; DTX: docetaxel; MAPKs: mitogen-actived protein kinases; PI3K/Akt: phosphatidylinositol 3-kinases (PI3K) /Akt; NF-Κb: the nuclear factor κB (NF-κB).
Keywords:
Curdione; chemo-sensitization; docetaxel; reactive oxygen species (ROS); triple-negative breast cancer (TNBC).
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / pharmacology*
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Apoptosis* / drug effects
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Docetaxel / pharmacology*
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Humans
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Mitogen-Activated Protein Kinases / metabolism
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Phosphatidylinositol 3-Kinases / metabolism
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Proto-Oncogene Proteins c-akt / metabolism
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Reactive Oxygen Species / metabolism*
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Sesquiterpenes, Germacrane / pharmacology*
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Signal Transduction / drug effects
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Triple Negative Breast Neoplasms / pathology*
Substances
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Reactive Oxygen Species
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Sesquiterpenes, Germacrane
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curdione
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Docetaxel
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Proto-Oncogene Proteins c-akt
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Mitogen-Activated Protein Kinases
Grants and funding
The author(s) reported there is no funding associated with the work featured in this article.