Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling

Xi-Yao Chen; Yang Jiao; Fu-Yang Zhang

doi:10.1186/s40779-021-00347-y

Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling

Mil Med Res. 2021 Oct 19;8(1):53. doi: 10.1186/s40779-021-00347-y.

Authors

Xi-Yao Chen¹, Yang Jiao², Fu-Yang Zhang³

Affiliations

¹ Department of Geriatrics, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China.
² Department of Stomatology, The 7th Medical Center of Chinese, PLA General Hospital, Beijing, 100700, China.
³ Department of Cardiology, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China. plazhangfuyang@163.com.

Abstract

The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling, emphasizing the therapeutic potential of PPARα activation strategies (e.g. fenofibrate treatment) in LT-associated cardiac injury.

Keywords: Cardiac dysfunction; Fatty acid metabolism; Low ambient temperature; Peroxisome proliferator-activated receptor-α; Remodeling.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Fenofibrate* / pharmacology
Fenofibrate* / therapeutic use
Heart Diseases* / etiology
Humans
PPAR alpha
Temperature

Substances

PPAR alpha
Fenofibrate