Polyhydroxylated steroids from the Vietnamese soft coral Sarcophyton ehrenbergi

Ninh Thi Ngoc; Tran Thi Hong Hanh; Tran Hong Quang; Nguyen Xuan Cuong; Nguyen Hoai Nam; Do Thi Thao; Do Cong Thung; Phan Van Kiem; Chau Van Minh

doi:10.1016/j.steroids.2021.108932

Polyhydroxylated steroids from the Vietnamese soft coral Sarcophyton ehrenbergi

Steroids. 2021 Dec:176:108932. doi: 10.1016/j.steroids.2021.108932. Epub 2021 Oct 15.

Authors

Ninh Thi Ngoc¹, Tran Thi Hong Hanh¹, Tran Hong Quang¹, Nguyen Xuan Cuong¹, Nguyen Hoai Nam², Do Thi Thao³, Do Cong Thung⁴, Phan Van Kiem¹, Chau Van Minh⁵

Affiliations

¹ Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
² Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: namnguyenhoai@imbc.vast.vn.
³ Institute of Biotechnology (IBT), VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
⁴ Institute of Marine Environment and Resources (IMER), VAST, 246 Da Nang, Haiphong, Viet Nam.
⁵ Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: cvminh@vast.vn.

PMID: 34662651
DOI: 10.1016/j.steroids.2021.108932

Abstract

Fourteen polyhydroxylated steroids including six new compounds, ehrensteroids A - F (1-6), were isolated from the Vietnamese soft coral Sarcophyton ehrenbergi after applying various chromatographic separations. The structure elucidation was done by detailed analysis of 1D, 2D NMR and HR QTOF mass spectra. In addition, significant cytotoxicity (IC₅₀ values ranging from 8.45 ± 0.56 to 38.27 ± 2.39 μM) against all five tested cancer cell lines as LU-1 (lung cancer), HepG2 (hepatoma cancer), MCF-7 (breast cancer), HL-60 (acute leukemia), and SW480 (colon adenocarcinoma) was observed for compounds 1, 2, 6-10, and 12-14, whereas this activity on LU-1 (IC₅₀ = 21.91 ± 2.72 μM) and HepG2 (IC₅₀ = 20.32 ± 0.03 μM) cell lines was also observed for 4.

Keywords: Cytotoxic activity; Polyhydroxylated steroids; Polyhydroxysteroids; Sarcophyton ehrenbergi; Soft coral.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Cell Survival / drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Molecular Conformation
Stereoisomerism
Steroids / chemistry
Steroids / isolation & purification
Steroids / pharmacology*
Structure-Activity Relationship

Substances

Antineoplastic Agents
Steroids