A general strategy for generating various Janus particles (JPs) based on shadow sphere lithography (SSL) by varying incident and azimuthal angles, as well as deposition numbers is introduced, forming well-identified flower-like patches on microsphere monolayers. An in-house simulation program is worked out to predict the patch morphology with complicated fabrication parameters. The predicted patch morphology matches quite well that of experimentally produced JPs. The relationships between patch shape/area/size/and incident angle/deposition numbers are quantitatively determined by calculating morphology and transmission spectrum correlations, which facilitated further implementation of SSL in fabricating more varieties of JPs. Such an SSL strategy can be used to create JPs with anticipated patch morphology and uniformity that may be used for self-assembly, drug delivery, or plasmonic sensors as well as exploring some fundamental principles relating to the properties of nanostructures.