Macrophage Activation Syndrome and COVID 19: Impact of MAPK Driven Immune-Epigenetic Programming by SARS-Cov-2

Front Immunol. 2021 Oct 1:12:763313. doi: 10.3389/fimmu.2021.763313. eCollection 2021.

Authors

Roshan Kumar Roy¹, Uttam Sharma², Mishi Kaushal Wasson¹, Aklank Jain², Md Imtaiyaz Hassan³, Hridayesh Prakash¹

Affiliations

¹ Amity Institute of Virology and Immunology, Amity University, NOIDA, Udham Singh Nagar, India.
² Department of Zoology, Central University of Punjab, Bathinda, India.
³ Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, India.

No abstract available

Keywords: COVID-19; MAPK; TLRs (toll-like receptors); immune polarization; inflammasome; lncRNAs; macrophage; miRNA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

COVID-19 / pathology*
Epigenesis, Genetic / genetics*
Humans
Immunity, Innate / genetics
Immunity, Innate / immunology
Lung / pathology
Macrophage Activation Syndrome / genetics
Macrophage Activation Syndrome / pathology*
Macrophages / immunology*
Respiratory Distress Syndrome / immunology
Respiratory Distress Syndrome / pathology
SARS-CoV-2
p38 Mitogen-Activated Protein Kinases / metabolism*

Substances

p38 Mitogen-Activated Protein Kinases