The meningeal lymphatics: regulators of Aβ immunotherapy?

Collin Laaker; Zsuzsanna Fabry

doi:10.1016/j.it.2021.09.011

The meningeal lymphatics: regulators of Aβ immunotherapy?

Trends Immunol. 2021 Nov;42(11):940-942. doi: 10.1016/j.it.2021.09.011. Epub 2021 Oct 13.

Authors

Collin Laaker¹, Zsuzsanna Fabry²

Affiliations

¹ Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI 53705, USA.
² Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI 53705, USA. Electronic address: zfabry@wisc.edu.

PMID: 34656427
DOI: 10.1016/j.it.2021.09.011

Abstract

A new study by Da Mesquita et al. reports on how meningeal lymphatic modulation may influence amyloid-beta immunotherapy and microglial function in mouse models of Alzheimer's disease (AD). This research has broad implications for unraveling the role meningeal lymphatics may play in regulating immunity in the brain during AD pathology and treatment.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Alzheimer Disease* / therapy
Amyloid beta-Peptides / metabolism
Animals
Brain
Disease Models, Animal
Humans
Immunotherapy
Lymphatic Vessels* / metabolism
Lymphatic Vessels* / pathology
Meninges / metabolism
Meninges / pathology
Mice
Mice, Transgenic

Substances

Amyloid beta-Peptides

Abstract

Publication types

MeSH terms

Substances

Grants and funding