Hyperpatulones C-G, new spirocyclic polycyclic polyprenylated acylphloroglucinols from the leaves of Hypericum patulum

Fitoterapia. 2021 Nov:155:105063. doi: 10.1016/j.fitote.2021.105063. Epub 2021 Oct 14.

Abstract

Five new spirocyclic polycyclic polyprenylated acylphloroglucinols, Hyperpatulones C-G (1-5), were obtained from the leaves of Hypericum patulum. Their structures were characterized by the comprehensive analysis of their IR, NMR, CD spectra and HRESIMS data. All the new compounds were evaluated for the α-glycosidase inhibitory activities. Among them, compounds 3-5 showed α-glucosidase inhibitory activities, with IC50 values of 14.06-37.69 μM.

Keywords: Hypericum patulum; Spirocyclic polycyclic polyprenylated acylphloroglucinols; α-Glucosidase inhibitory activity.

MeSH terms

  • China
  • Glycoside Hydrolase Inhibitors / isolation & purification
  • Glycoside Hydrolase Inhibitors / pharmacology*
  • Hypericum / chemistry*
  • Molecular Structure
  • Phloroglucinol / isolation & purification
  • Phloroglucinol / pharmacology*
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Leaves / chemistry
  • alpha-Glucosidases

Substances

  • Glycoside Hydrolase Inhibitors
  • Phytochemicals
  • Phloroglucinol
  • alpha-Glucosidases