A metal-polyphenolic nanosystem with NIR-II fluorescence-guided combined photothermal therapy and radiotherapy

Jie Li; Wenxi Li; Lisi Xie; Wei Sang; Guohao Wang; Zhan Zhang; Bei Li; Hao Tian; Jie Yan; Ye Tian; Zhenhua Li; Quli Fan; Lin Yu; Yunlu Dai

doi:10.1039/d1cc04628d

A metal-polyphenolic nanosystem with NIR-II fluorescence-guided combined photothermal therapy and radiotherapy

Chem Commun (Camb). 2021 Nov 2;57(87):11473-11476. doi: 10.1039/d1cc04628d.

Authors

Jie Li^{1

2}, Wenxi Li^{1

2}, Lisi Xie^{1

2}, Wei Sang^{1

2}, Guohao Wang^{1

2}, Zhan Zhang^{1

2}, Bei Li^{1

2}, Hao Tian^{1

2}, Jie Yan^{1

2}, Ye Tian^{1

2}, Zhenhua Li³, Quli Fan⁴, Lin Yu⁵, Yunlu Dai^{1

2}

Affiliations

¹ Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China. yldai@um.edu.mo.
² MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR 999078, China.
³ Affiliated Dongguan Hospital, Southern Medical University, Dongguan 523059, China.
⁴ Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, Nanjing 210023, China.
⁵ State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China.

PMID: 34652356
DOI: 10.1039/d1cc04628d

Abstract

Photothermal therapy (PTT) achieves substantive therapeutic progress in certain tumor types without exogenous agents but is hampered by the over-activated inflammatory response or tumor recurrence in some cases. Herein, we technically developed the metal-polyphenolic nanosystem with precise NIR-II fluorescence-imaging guidance for combining hafnium (Hf)-sensitized radiotherapy with PTT to regress tumor growth.

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / therapeutic use*
Cell Line, Tumor
Dopamine / analogs & derivatives
Female
Fluorescence
Fluorescent Dyes / chemistry
Fluorescent Dyes / therapeutic use*
Hafnium / chemistry
Hafnium / therapeutic use
Mice
Mice, Inbred BALB C
Mice, Nude
Nanoparticles / chemistry
Nanoparticles / therapeutic use*
Neoplasms / diagnostic imaging
Neoplasms / drug therapy*
Neoplasms / radiotherapy*
Photothermal Therapy
Poloxamer / chemistry
Radiopharmaceuticals / chemistry
Radiopharmaceuticals / therapeutic use*
Radiotherapy

Substances

Antineoplastic Agents
Fluorescent Dyes
Radiopharmaceuticals
Poloxamer
Dopamine
Hafnium