Abstract
We report the first synthesis and immunological evaluation of a new glycoconjugate design based on streamlined saponin adjuvants and the Tn carbohydrate antigen. While the novel synthetic constructs induced moderate antibody responses in mice, the versatile chemical platform is amenable to further structure-activity optimizations for the development of self-adjuvanting glycoconjugate cancer vaccines.
MeSH terms
-
Adjuvants, Immunologic / chemistry*
-
Animals
-
Antibody Formation
-
Antigens, Tumor-Associated, Carbohydrate / chemistry*
-
Cancer Vaccines / chemistry
-
Carbohydrates / chemistry
-
Female
-
Glycoconjugates / chemistry*
-
Humans
-
Mice
-
Mice, Inbred C57BL
-
Molecular Structure
-
Saponins / chemistry*
-
Structure-Activity Relationship
Substances
-
Adjuvants, Immunologic
-
Antigens, Tumor-Associated, Carbohydrate
-
Cancer Vaccines
-
Carbohydrates
-
Glycoconjugates
-
Saponins
-
Tn antigen