Cell-Based Transplantation versus Cell Homing Approaches for Pulp-Dentin Complex Regeneration

Geraldine M Ahmed; Eman A Abouauf; Nermeen AbuBakr; Asmaa M Fouad; Christof E Dörfer; Karim M Fawzy El-Sayed

doi:10.1155/2021/8483668

Cell-Based Transplantation versus Cell Homing Approaches for Pulp-Dentin Complex Regeneration

Stem Cells Int. 2021 Sep 29:2021:8483668. doi: 10.1155/2021/8483668. eCollection 2021.

Authors

Geraldine M Ahmed^{1

2}, Eman A Abouauf^{1

3}, Nermeen AbuBakr^{1

4}, Asmaa M Fouad², Christof E Dörfer⁵, Karim M Fawzy El-Sayed^{1

5

6}

Affiliations

¹ Stem Cell and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt.
² Department of Endodontics, Faculty of Dentistry, Cairo University, Cairo, Egypt.
³ Department of Conservative Dentistry, Faculty of Dentistry, Cairo University, Cairo, Egypt.
⁴ Oral Biology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.
⁵ Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian Albrechts University, Kiel, Germany.
⁶ Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.

Abstract

Regenerative dentistry has paved the way for a new era for the replacement of damaged dental tissues. Whether the causative factor is dental caries, trauma, or chemical insult, the loss of the pulp vitality constitutes one of the major health problems worldwide. Two regenerative therapies were introduced for a fully functional pulp-dentin complex regeneration, namely, cell-based (cell transplantation) and cell homing (through revascularization or homing by injection of stem cells in situ or intravenously) therapies, with each demonstrating advantages as well as drawbacks, especially in clinical application. The present review is aimed at elaborating on these two techniques in the treatment of irreversibly inflamed or necrotic pulp, which is aimed at regenerating a fully functional pulp-dentin complex.

Publication types

Review