A novel linear and broadly neutralizing peptide in the SARS-CoV-2 S2 protein for universal vaccine development

Tuofan Li; Qiuqi Kan; Jinying Ge; Zhimin Wan; Mengqi Yuan; Yao Huang; Quan Xie; Yi Yang; Hongxia Shao; Xiangdong Li; Lilin Ye; Aijian Qin; Zhigao Bu; Pinghuang Liu; Jianqiang Ye

doi:10.1038/s41423-021-00778-6

A novel linear and broadly neutralizing peptide in the SARS-CoV-2 S2 protein for universal vaccine development

Cell Mol Immunol. 2021 Nov;18(11):2563-2565. doi: 10.1038/s41423-021-00778-6. Epub 2021 Oct 13.

Authors

Tuofan Li^#^{1

2

3

4}, Qiuqi Kan^#^{1

2

3

4}, Jinying Ge^#^{5

6}, Zhimin Wan^#^{1

2

3

4}, Mengqi Yuan⁷, Yao Huang⁸, Quan Xie^{1

2

3

4}, Yi Yang^{1

2

3

4}, Hongxia Shao^{1

2

3

4}, Xiangdong Li^{1

2

3

4}, Lilin Ye^{7

9}, Aijian Qin^{10

11

12

13}, Zhigao Bu^{14

15}, Pinghuang Liu¹⁶, Jianqiang Ye^{17

18

19

20}

Affiliations

¹ Jiangsu Coinnovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, Jiangsu, China.
² Key Laboratory of Jiangsu Preventive Veterinary Medicine, Key Laboratory for Avian Preventive Medicine, Ministry of Education, College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China.
³ Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, 225009, Jiangsu, China.
⁴ Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou, 225009, Jiangsu, China.
⁵ State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 150069, Harbin, China.
⁶ National High Containment Laboratory for Animal Diseases Control and Prevention, 150069, Harbin, China.
⁷ College of Veterinary Medicine, China Agricultural University, 100193, Beijing, China.
⁸ Center of Diseases Control and Prevention, Yangzhou, 225009, Jiangsu, China.
⁹ Institute of Immunology, PLA, Third Military Medical University, 400038, Chongqing, China.
¹⁰ Jiangsu Coinnovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, Jiangsu, China. aijian@yzu.edu.cn.
¹¹ Key Laboratory of Jiangsu Preventive Veterinary Medicine, Key Laboratory for Avian Preventive Medicine, Ministry of Education, College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China. aijian@yzu.edu.cn.
¹² Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, 225009, Jiangsu, China. aijian@yzu.edu.cn.
¹³ Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou, 225009, Jiangsu, China. aijian@yzu.edu.cn.
¹⁴ State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 150069, Harbin, China. buzhigao@caas.cn.
¹⁵ National High Containment Laboratory for Animal Diseases Control and Prevention, 150069, Harbin, China. buzhigao@caas.cn.
¹⁶ College of Veterinary Medicine, China Agricultural University, 100193, Beijing, China. liupinghuang@cau.edu.cn.
¹⁷ Jiangsu Coinnovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, Jiangsu, China. jqye@yzu.edu.cn.
¹⁸ Key Laboratory of Jiangsu Preventive Veterinary Medicine, Key Laboratory for Avian Preventive Medicine, Ministry of Education, College of Veterinary Medicine, Yangzhou University, Yangzhou, 225009, Jiangsu, China. jqye@yzu.edu.cn.
¹⁹ Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou, 225009, Jiangsu, China. jqye@yzu.edu.cn.
²⁰ Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou, 225009, Jiangsu, China. jqye@yzu.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Neutralizing / chemistry*
Antibodies, Viral / immunology
COVID-19 / genetics
COVID-19 / immunology*
Chlorocebus aethiops
Enzyme-Linked Immunosorbent Assay
Epitopes / chemistry
HEK293 Cells
Humans
Mice
Mutation
Neutralization Tests*
Peptides / chemistry*
Protein Domains
SARS-CoV-2 / chemistry
SARS-CoV-2 / immunology*
Vero Cells

Substances

Antibodies, Neutralizing
Antibodies, Viral
Epitopes
Peptides