Fat mesenchyme closes the neural-ILC2 circuit

Xia Meng; Wenwen Zeng

doi:10.1016/j.immuni.2021.09.012

Fat mesenchyme closes the neural-ILC2 circuit

Immunity. 2021 Oct 12;54(10):2191-2193. doi: 10.1016/j.immuni.2021.09.012.

Authors

Xia Meng¹, Wenwen Zeng²

Affiliations

¹ Institute for Immunology and Department of Basic Medical Sciences, School of Medicine, Tsinghua University, and Tsinghua-Peking Center for Life Sciences, Beijing 100084, China; Beijing Key Laboratory for Immunological Research on Chronic Diseases, Beijing 100084, China.
² Institute for Immunology and Department of Basic Medical Sciences, School of Medicine, Tsinghua University, and Tsinghua-Peking Center for Life Sciences, Beijing 100084, China; Beijing Key Laboratory for Immunological Research on Chronic Diseases, Beijing 100084, China. Electronic address: wenwenzeng@tsinghua.edu.cn.

PMID: 34644555
DOI: 10.1016/j.immuni.2021.09.012

Abstract

The immune milieu and neuronal activity each impact adipose metabolic health, yet their interplay remains largely undefined. In a recent issue of Nature, Cardoso et al. uncover a sympathetic neuro-mesenchymal-ILC2s circuit from brain-to-fat controlling obesity and glucose metabolism.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adipose Tissue
Humans
Immunity, Innate*
Lymphocytes*
Mesoderm
Obesity