One-Pot Synthesis of Symmetrical and Asymmetrical 3-Amino Diynes via Cu(I)-Catalyzed Reaction of Enaminones with Terminal Alkynes

Changyuan Zhang; Huosheng Guo; Lulu Chen; Jiantao Zhang; Mengping Guo; Xuncheng Zhu; Chan Shen; Zeng Li

doi:10.1021/acs.orglett.1c02848

One-Pot Synthesis of Symmetrical and Asymmetrical 3-Amino Diynes via Cu(I)-Catalyzed Reaction of Enaminones with Terminal Alkynes

Org Lett. 2021 Nov 5;23(21):8169-8173. doi: 10.1021/acs.orglett.1c02848. Epub 2021 Oct 12.

Authors

Changyuan Zhang¹, Huosheng Guo¹, Lulu Chen¹, Jiantao Zhang², Mengping Guo¹, Xuncheng Zhu¹, Chan Shen¹, Zeng Li¹

Affiliations

¹ Key Laboratory of Jiangxi University for Applied Chemistry and Chemical Biology, College of Chemistry and Bio-engineering, Yichun University, Yichun 336000, P.R. China.
² College of Chemistry, Guangdong University of Petrochemical Technology, Guandu Road, Maoming 525000, P. R. China.

PMID: 34636564
DOI: 10.1021/acs.orglett.1c02848

Abstract

An economical and efficient protocol for the direct construction of amino skipped diynes through the Cu(I)-catalyzed reaction of enaminones and terminal alkynes has been described. Different kinds of symmetrical and asymmetrical 3-amino diynes could be obtained in up to 83% yield through a one-pot reaction under mild conditions.