Mesenchymal stem/stromal cell therapy in atopic dermatitis and chronic urticaria: immunological and clinical viewpoints

Stem Cell Res Ther. 2021 Oct 11;12(1):539. doi: 10.1186/s13287-021-02583-4.

Abstract

Allergic diseases are immune-mediated diseases. Allergies share a common immunopathogenesis, with specific differences according to the specific disease. Mesenchymal stem/stromal cells (MSCs) have been applied to people suffering from allergic and many other diseases. In this review, the immunologic roles of MSCs are systemically reviewed according to disease immunopathogenesis from a clinical viewpoint. MSCs seem to be a promising therapeutic modality not only as symptomatic treatments but also as causative and even preventive treatments for allergic diseases, including atopic dermatitis and chronic urticaria.

Keywords: Allergy; Atopic dermatitis; Chronic urticaria; Clinical viewpoint; Mesenchymal stem/stromal cell.

Publication types

  • Review

MeSH terms

  • Chronic Urticaria*
  • Dermatitis, Atopic* / therapy
  • Humans
  • Hypersensitivity*
  • Mesenchymal Stem Cells*